Prenatal diagnosis · 2007
Failure of second-trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Tikkanen Minna, Stenman Ulf-Håkan, Nuutila Mika, Paavonen Jorma, Hiilesmaa Vilho, Ylikorkala Olavi
Аннотация
OBJECTIVE: High level of soluble endoglin (sEng), a potent antiangiogenic factor, predicts pre-eclampsia. We compared the serum levels of sEng in early second trimester in women with and without subsequent placental abruption. Proangiogenic placental growth factor (PlGF) and antiangiogenic soluble fms-like tyrosine kinase 1 (sFlt-1) were also studied.
METHODS: Serum samples of 42 women with placental abruption and 50 control women, collected at 15 to 16 gestational weeks were analyzed for sEng, sFlt-1 and PlGF by immunoassays.
RESULTS: The levels of sEng showed no difference between the cases and controls, but parous or smoking women with abruption had lower levels of sEng. Similarly, sFlt-1, PlGF, or sFlt-1/PlGF ratio showed no difference between the cases and the controls.
CONCLUSION: Our data suggest that sEng, PlGF and sFlt-1 levels in early second trimester fail to predict placental abruption.
METHODS: Serum samples of 42 women with placental abruption and 50 control women, collected at 15 to 16 gestational weeks were analyzed for sEng, sFlt-1 and PlGF by immunoassays.
RESULTS: The levels of sEng showed no difference between the cases and controls, but parous or smoking women with abruption had lower levels of sEng. Similarly, sFlt-1, PlGF, or sFlt-1/PlGF ratio showed no difference between the cases and the controls.
CONCLUSION: Our data suggest that sEng, PlGF and sFlt-1 levels in early second trimester fail to predict placental abruption.