Journal of global health · 2026
Levels and determinants of child wasting relapse: a prospective cohort study from Somalia.
СтатьяНазвание и аннотация: Перевод в очереди
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Alier Kemish Kenneth, Walton Shelley, Grounds Samantha, Garretson Sydney, Mohamoud Said Aden, Nur Mohamud Ali, Abdiqadir Sadiq Mohamed, Mahat Mohamed Billow, P'Rajom Michael Ocircan, Ismail Meftuh Omer, Farah Abdullahi Abdulle, Khattak Qundeel, Schofield Lilly, Tripaldi Marina, Loddo Fabrizio, Sinibaldi Pierluigi, Mohamed Farhan, Mohamed Abdifatah Ahmed, Mohamed Adam Abdulkadir, Akseer Nadia
Аннотация
BACKGROUND: Understanding the rates and determinants of severe acute malnutrition (SAM) relapse is crucial for stakeholders in Somalia, where evidence is limited. This study aimed to assess SAM relapse rates and associated risk factors among children discharged from outpatient therapeutic programmes (OTP) in the Bay and Hiran regions of Somalia.
METHODS: We conducted a prospective cohort study of 160 children aged 7-53 months discharged as recovered from OTP SAM treatment between August-September 2023. Children were followed monthly for six time points post-discharge. Anthropometric measurements, morbidity data, and household information were collected. Survival analysis was used to calculate cumulative incidence of SAM relapse, defined by weight-for-height z-score (WHZ)<-3 standard deviation (SD) or mid-upper arm circumference (MUAC)<11.5 cm or oedema. Cox proportional hazard models identified factors associated with relapse.
RESULTS: Cumulative incidence of SAM relapse at Time 1 (T1) = 5.2% (95% confidence interval (CI) = 2.5, 10.6%), T2 = 14.3% (95% CI = 9.4, 21.5%) and T6 = 26.0% (95% CI = 19.3, 34.5%) by WHZ and 13.2% (95% CI = 8.8, 19.5%) by MUAC. The relapse rate for combined SAM and moderate acute malnutrition by WHZ at T1 = 26.9% (95% CI = 19.5, 36.3%), T2 = 36.2% (95% CI = 28.0, 46.1%) and T6 = 50.1% (95% CI = 41.0, 60.0%). Weight-for-height z-score (WHZ)-based relapse was higher in rural areas (31.4% vs. 22.7% urban, P = 0.285) and among children with WHZ<-3 SD at admission (37.4% vs. 21.2%, P = 0.029). Mid-upper arm circumference (MUAC)-based relapse was higher in urban areas (20.8% vs. 4.1% rural, P = 0.002), among younger children (19.7% vs. 5.5% > 2 years, P = 0.009), and internally displaced persons (21.8% vs. 5.8% non-internally displaced persons, P = 0.003). Factors significantly associated with increased relapse risk included WHZ<-3 SD at admission (adjusted hazard ratio (HR) = 2.22; 95% CI = 1.04, 4.72) and longer OTP stay (adjusted HR = 1.02 per day; 95% CI = 1.00, 1.04). Participation in a cash assistance programme was protective (adjusted HR = 0.44; 95% CI = 0.22, 0.90).
CONCLUSIONS: Severe acute malnutrition (SAM) relapse rates in Somalia are considerable, with varying patterns by anthropometric indicator, region, and demographic factors. Cash assistance programme offers a promising complementary intervention. These findings can inform targeted interventions and policy changes to reduce relapse and improve long-term outcomes for children recovering from SAM in Somalia and similar contexts.
REGISTRATION: The cluster-RCT associated with this cohort study is registered at ClinicalTrials.gov, ID: NCT06642012.
METHODS: We conducted a prospective cohort study of 160 children aged 7-53 months discharged as recovered from OTP SAM treatment between August-September 2023. Children were followed monthly for six time points post-discharge. Anthropometric measurements, morbidity data, and household information were collected. Survival analysis was used to calculate cumulative incidence of SAM relapse, defined by weight-for-height z-score (WHZ)<-3 standard deviation (SD) or mid-upper arm circumference (MUAC)<11.5 cm or oedema. Cox proportional hazard models identified factors associated with relapse.
RESULTS: Cumulative incidence of SAM relapse at Time 1 (T1) = 5.2% (95% confidence interval (CI) = 2.5, 10.6%), T2 = 14.3% (95% CI = 9.4, 21.5%) and T6 = 26.0% (95% CI = 19.3, 34.5%) by WHZ and 13.2% (95% CI = 8.8, 19.5%) by MUAC. The relapse rate for combined SAM and moderate acute malnutrition by WHZ at T1 = 26.9% (95% CI = 19.5, 36.3%), T2 = 36.2% (95% CI = 28.0, 46.1%) and T6 = 50.1% (95% CI = 41.0, 60.0%). Weight-for-height z-score (WHZ)-based relapse was higher in rural areas (31.4% vs. 22.7% urban, P = 0.285) and among children with WHZ<-3 SD at admission (37.4% vs. 21.2%, P = 0.029). Mid-upper arm circumference (MUAC)-based relapse was higher in urban areas (20.8% vs. 4.1% rural, P = 0.002), among younger children (19.7% vs. 5.5% > 2 years, P = 0.009), and internally displaced persons (21.8% vs. 5.8% non-internally displaced persons, P = 0.003). Factors significantly associated with increased relapse risk included WHZ<-3 SD at admission (adjusted hazard ratio (HR) = 2.22; 95% CI = 1.04, 4.72) and longer OTP stay (adjusted HR = 1.02 per day; 95% CI = 1.00, 1.04). Participation in a cash assistance programme was protective (adjusted HR = 0.44; 95% CI = 0.22, 0.90).
CONCLUSIONS: Severe acute malnutrition (SAM) relapse rates in Somalia are considerable, with varying patterns by anthropometric indicator, region, and demographic factors. Cash assistance programme offers a promising complementary intervention. These findings can inform targeted interventions and policy changes to reduce relapse and improve long-term outcomes for children recovering from SAM in Somalia and similar contexts.
REGISTRATION: The cluster-RCT associated with this cohort study is registered at ClinicalTrials.gov, ID: NCT06642012.