JPMA. The Journal of the Pakistan Medical Association · 2021
Follicular fluid vascular endothelial growth factor in normal and hyperresponder females and how it is affected by the type of trigger.
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Mahmood Muna Kasim, Alsultany Batool Abdzaid, Jassim Inass Yasien
Аннотация
OBJECTIVE: To study the type of trigger affecting the level of vascular endothelial growth factor in the follicular fluid of normal and hyper-responder females aiming to decrease the occurrence of ovarian hyper- stimulated syndrome.
METHODS: A total of 87 females with infertility, attending the Al sadder center in AL-Najaf Al -Ashraf city, for IVF were included in the study. PCOS were present in 48 women and the remaining had other causes of infertility. All of them used antagonist protocol and gonadotrophin. Triggering of ovulation was induced by hCG in non PCOS and GnRH- agonist in PCOS. Transvaginal aspiration of the follicles and measurement of follicular fluid VEGF was done.
RESULTS: A total of 87 infertile females were included in the study. They were divided in 2 groups; hyper -responders (48 cases)and normal responders 39 cases with male causes and tubal and unexplained etiology. No significant difference was observed between the hyper responders and the normal responders regarding age and BMI, (P<0.313 and 0.721 respectively) Using GnRH agonist as a trigger of ovulation in females with PCOS, lowering the level of VEGF, decreases the risk of developing OHSS.
CONCLUSIONS: using the GNRH agonist instead of hCG as a trigger in females with PCOS lowers the risk of developing OHSS.
METHODS: A total of 87 females with infertility, attending the Al sadder center in AL-Najaf Al -Ashraf city, for IVF were included in the study. PCOS were present in 48 women and the remaining had other causes of infertility. All of them used antagonist protocol and gonadotrophin. Triggering of ovulation was induced by hCG in non PCOS and GnRH- agonist in PCOS. Transvaginal aspiration of the follicles and measurement of follicular fluid VEGF was done.
RESULTS: A total of 87 infertile females were included in the study. They were divided in 2 groups; hyper -responders (48 cases)and normal responders 39 cases with male causes and tubal and unexplained etiology. No significant difference was observed between the hyper responders and the normal responders regarding age and BMI, (P<0.313 and 0.721 respectively) Using GnRH agonist as a trigger of ovulation in females with PCOS, lowering the level of VEGF, decreases the risk of developing OHSS.
CONCLUSIONS: using the GNRH agonist instead of hCG as a trigger in females with PCOS lowers the risk of developing OHSS.