Optimal respiratory support for extremely low birth weight infants - do we have the answers?

Survival rates for extremely low birth weight (ELBW) infants have improved over the recent years, yet morbidity remains high. This review explores respiratory management strategies for this unique cohort and how it may impact their long-term outcomes. Although there is a preference towards non-invasive respiratory support in less immature infants, ELBW infants often require invasive ventilation. This comes with an increased risk of bronchopulmonary dysplasia, adverse neurodevelopmental outcomes and lifelong respiratory impairment. There are a range of options available to reduce volutrauma and minimise lung injury, including volume targeted ventilation and high-frequency ventilation. In the absence of high-quality evidence focussing on ELBW infants, much of current practice is inferred from studies involving infants with a broader range of gestational ages and experiences at high-volume centres. This highlights the need for further research targeted to this specific population with a focus on long-term respiratory health.