Acta clinica Belgica · 2026
A structured proactive penicillin allergy delabeling intervention in adult patients in three non-university hospitals.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Langbeen Jodie, Desmyttere Evy, Delaere Evelien, Dobbelaere Stephanie, Tits Geert, Soenen Ann-Catherine, Malysse Ines, Missiaen Laetitia, Vanwynsberghe Sarah, Van Huffel Kristof, Santens Hannelore, Van Hoecke Frederik, Terryn Wim, Vogelaers Dirk
Аннотация
BACKGROUND: Over 90% of patients with penicillin allergy do not have a true penicillin allergy. This allergy label can lead to inappropriate antibiotic prescription, a higher risk of treatment failure and toxicity, and higher rates of infections with multidrug-resistant organisms. Penicillin allergy delabeling strategies are increasingly reported and should be included in antimicrobial stewardship programs.
OBJECTIVES AND METHODS: Development and phased implementation of a structured and proactive screening tool and decision algorithm for delabeling presumed penicillin allergy in the preoperative consultations of three non-university hospitals within the same locoregional network. Risk categorization was integrated into a user-friendly screening questionnaire, and streamlined actions were developed through interdisciplinary consensus.
RESULTS: The questionnaire was implemented in two pilot phases, with adaptations through feedback from the users and other hospital networks working on penicillin allergy delabeling throughout Flanders. Among a total of 8.659 patients screened, 600 patients (6.93%) reported penicillin allergy, categorized as no risk, low, or high risk of penicillin allergy. 91 patients (15.17%) could be directly delabeled, and 33 patients (5.5%) were delabeled through patient file analysis or further testing.
CONCLUSION: A screening tool for proactive detection of penicillin allergy was developed. This study demonstrates that a substantial proportion of patients with a presumed penicillin allergy can be delabeled non-medically by administering a structured questionnaire, offering a step up towards comprehensive allergologic questioning and patient file analysis, with eventual additional testing in selected patients. The screening tool needs to be validated in a prospective trial including definitive categorization.
OBJECTIVES AND METHODS: Development and phased implementation of a structured and proactive screening tool and decision algorithm for delabeling presumed penicillin allergy in the preoperative consultations of three non-university hospitals within the same locoregional network. Risk categorization was integrated into a user-friendly screening questionnaire, and streamlined actions were developed through interdisciplinary consensus.
RESULTS: The questionnaire was implemented in two pilot phases, with adaptations through feedback from the users and other hospital networks working on penicillin allergy delabeling throughout Flanders. Among a total of 8.659 patients screened, 600 patients (6.93%) reported penicillin allergy, categorized as no risk, low, or high risk of penicillin allergy. 91 patients (15.17%) could be directly delabeled, and 33 patients (5.5%) were delabeled through patient file analysis or further testing.
CONCLUSION: A screening tool for proactive detection of penicillin allergy was developed. This study demonstrates that a substantial proportion of patients with a presumed penicillin allergy can be delabeled non-medically by administering a structured questionnaire, offering a step up towards comprehensive allergologic questioning and patient file analysis, with eventual additional testing in selected patients. The screening tool needs to be validated in a prospective trial including definitive categorization.