Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2008
[Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Deng Gui-feng, Yao Tong-wei
Аннотация
OBJECTIVE: To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.
METHODS: An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.
RESULT: Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.
CONCLUSION: The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.
METHODS: An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.
RESULT: Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.
CONCLUSION: The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.