Respirology case reports · 2025
Successful Treatment of Steroid-Dependent Severe Eosinophilic Pneumonia With Benralizumab: A Case Report.
СтатьяНазвание и аннотация: Перевод в очереди
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Ichikawa Takeru, Takigawa Yuki, Fujiwara Keiichi, Inoue Tomoyoshi, Matsumoto Shoichiro, Shiraha Keisuke, Goda Mayu, Matsuoka Suzuka, Watanabe Hiromi, Kudo Kenichiro, Sato Akiko, Sato Ken, Shibayama Takuo
Аннотация
Eosinophilic pneumonia (EP) often requires long-term steroid treatment, which has adverse effects. We report the case of an 83-year-old male with minimal-change nephrotic syndrome, refractory asthma and steroid-induced diabetes who developed a severe steroid-dependent EP relapse during steroid tapering. Considering his age, comorbidities and steroid dependency, treatment with benralizumab, an anti-interleukin-5 receptor antibody, was initiated. Benralizumab rapidly depleted eosinophils, leading to significant clinical and radiological improvements, allowing successful sustained tapering of prednisolone to 5 mg daily, and improving diabetes control without EP relapse. Benralizumab provides effective steroid-sparing therapy for steroid-dependent EP, particularly in complex patients.