Harmful algae · 2016
Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Lopez Maria-Cecilia, Ungaro Ricardo F, Baker Henry V, Moldawer Lyle L, Robertson Alison, Abbott Margaret, Roberts Sparkle M, Grattan Lynn M, Morris J Glenn
Аннотация
Ciguatera fish poisoning (ciguatera) is a common clinical syndrome in areas where there is dependence on tropical reef fish for food. A subset of patients develops recurrent and, in some instances, chronic symptoms, which may result in substantial disability. To identify possible biomarkers for recurrent/chronic disease, and to explore correlations with immune gene expression, peripheral blood leukocyte gene expression in 10 ciguatera patients (7 recurrent and 3 acute) from the U.S. Virgin Islands, and 5 unexposed Florida controls were evaluated. Significant differences in gene expression were noted when comparing ciguatera patients and controls; however, it was not possible to differentiate between patients with acute and recurrent disease, possibly due to the small sample sizes involved.