Eye science · 2012
Analysis of the activation of the Nrf2-ARE pathway following optic nerve injury in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yan Feng, Chen Sui Hua, Li Xiang Jun, Nie Chuang, Xie Hai Nan
Аннотация
PURPOSE: The Nrf2-ARE pathway plays a cytoprotective role in many tissues,but its protective function in the optic nerve is unclear. The purpose of the study is to investigate the changes in activation of the Nrf2-ARE pathway following optic nerve injury (ONI) in mice.
METHODS: Using ONI mice models, the expression levels of Nrf2 in optic nerves were determined by real-time PCR at various time points.
RESULTS: The expression of Nrf2mRNA was significantly upregulated at 1 d after ONI, peaking at 30 min after ONI.
CONCLUSION: The Nrf2-ARE pathway was activated after ONI, providing evidence for the study of the protection and underlying mechanism of Nrf2-ARE pathway on optic nerves.
METHODS: Using ONI mice models, the expression levels of Nrf2 in optic nerves were determined by real-time PCR at various time points.
RESULTS: The expression of Nrf2mRNA was significantly upregulated at 1 d after ONI, peaking at 30 min after ONI.
CONCLUSION: The Nrf2-ARE pathway was activated after ONI, providing evidence for the study of the protection and underlying mechanism of Nrf2-ARE pathway on optic nerves.