[Clinicopathologic investigation of 63 cases of pituitary adenoma--special reference to immunohistochemical study of hormone production].

We have referred 63 cases of pituitary adenoma during past 10 years at department pathology of Hokkaido University Hospital. The mean age at diagnosis was 38 years, with a range from 13 to 73 years. 35 patients complained of non-hormonal sign (head ache, disturbance of vision, disturbance of consciousness, fatigability), 32 patients presented with hormonal sign (acromegaly, troubles of menstruation, galactorrhoea, cushing syndrome) and 7 patients had both signs. Immunohistochemically, GH cell adenoma was 16 cases, Prolactine cell adenoma was 11 cases, ACTH cell adenoma was 4 cases, Non-functioning adenoma was 19 cases and Mixed type was 10 cases.