The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026
A prospective study on maternal and neonatal outcomes and influencing factors in pregnant women with borderline hypertension.
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Chen Wenmei, Tang Xiaotong, Sun Lizhou, Wu Dan, Zhang Yuanyuan
Аннотация
OBJECTIVE: To investigate maternal and neonatal outcomes and influencing factors in pregnant women with borderline hypertension.
METHODS: This prospective cohort study consecutively enrolled 600 pregnant women receiving prenatal care at two hospitals between January 1 and December 31, 2024. Participants were divided into a normotensive control group (n = 300) and a borderline hypertension group (systolic 130-139 mmHg and/or diastolic 80-89 mmHg, n = 300). The primary outcome was progression to hypertensive disorders of pregnancy (HDP). Maternal and neonatal outcomes were compared, and influencing factors were analyzed.
RESULTS: Women with borderline hypertension exhibited significantly higher rates of cesarean delivery (63.0% vs. 42.0%; p < 0.001), HDP progression (27.0% vs. 0.0%; p < 0.001), fetal growth restriction (15.7% vs. 2.7%; p < 0.001), and NICU admission (13.7% vs. 4.0%; p < 0.001) compared to normotensive controls. Notably, later gestational age at onset of borderline hypertension was identified as a protective factor against HDP progression (OR = 0.785 per week; 95% CI: 0.724-0.851; p < 0.001), corresponding to a 21.5% risk reduction for each delayed week of onset.
CONCLUSION: Borderline hypertension is associated with markedly increased adverse perinatal outcomes. Early detection and intervention-especially for women developing borderline elevation before 20 weeks-may help mitigate HDP progression. Integrating blood pressure trajectory monitoring into routine prenatal care is recommended.
METHODS: This prospective cohort study consecutively enrolled 600 pregnant women receiving prenatal care at two hospitals between January 1 and December 31, 2024. Participants were divided into a normotensive control group (n = 300) and a borderline hypertension group (systolic 130-139 mmHg and/or diastolic 80-89 mmHg, n = 300). The primary outcome was progression to hypertensive disorders of pregnancy (HDP). Maternal and neonatal outcomes were compared, and influencing factors were analyzed.
RESULTS: Women with borderline hypertension exhibited significantly higher rates of cesarean delivery (63.0% vs. 42.0%; p < 0.001), HDP progression (27.0% vs. 0.0%; p < 0.001), fetal growth restriction (15.7% vs. 2.7%; p < 0.001), and NICU admission (13.7% vs. 4.0%; p < 0.001) compared to normotensive controls. Notably, later gestational age at onset of borderline hypertension was identified as a protective factor against HDP progression (OR = 0.785 per week; 95% CI: 0.724-0.851; p < 0.001), corresponding to a 21.5% risk reduction for each delayed week of onset.
CONCLUSION: Borderline hypertension is associated with markedly increased adverse perinatal outcomes. Early detection and intervention-especially for women developing borderline elevation before 20 weeks-may help mitigate HDP progression. Integrating blood pressure trajectory monitoring into routine prenatal care is recommended.