[Danol (danazol) in the treatment of fibrocystic breast disease with mastodynia].

The author investigated in a group of 12 premenopausal women with fibrocystic mastopathy with mastodynia, confirmed on mammography, the effectiveness of a synthetic ethisterone derivative--danazole. An objective effect (reduction of the number and/or diminution of nodularities in the mammary parenchyma) was achieved in 67%, disappearance of mastodynia in 100%. As to side-effects only amenorrhoea was observed in 92%, spotting in 8%, an increase of body weight (1-6 kg) in 83% of the treated women. Danol will, with regard to its effectiveness and very good tolerance, if more widely available, substantially extend our therapeutic possibilities in the above indication.