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Войти в исследования Toxicon : official journal of the International Society on Toxinology · 2024
The changes and the potential clinical applications of cytokines in Taiwan's major venomous snakebites patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Lin Chih-Chuan, Wang Chia-Cheng, Ou Yang Chun-Hsiang, Liu Chien-Chun, Yu Jau-Song, Fann Wen-Chih, Chen Yen-Chia, Shih Chia-Pang
Аннотация
BACKGROUND: Taiwan habu (Protobothrops mucrosquamatus), green bamboo viper (Viridovipera stejnegeri), and Taiwan cobra (Naja atra) are the most venomous snakebites in Taiwan. Patients commonly present with limb swelling but misdiagnosis rates are high, and currently available diagnostic tools are limited. This study explores the immune responses in snakebite patients to aid in differential diagnosis.
METHODS: This prospective observational study investigated the changes in cytokines in snakebite patients and their potential for diagnosis.
RESULTS: Elevated pro-inflammatory cytokines IL-6 and TNF-α were observed in all snakebite patients compared to the healthy control group. While no significant disparities were observed in humoral immune response cytokines, there were significant differences in IFN-γ levels, with significantly higher IL-10 levels in patients bitten by cobras. Patients with TNF-α levels exceeding 3.02 pg/mL were more likely to have been bitten by a cobra.
CONCLUSION: This study sheds light on the immune responses triggered by various venomous snakebites, emphasizing the potential of cytokine patterns for snakebite-type differentiation. Larger studies are needed to validate these findings for clinical use, ultimately improving snakebite diagnosis and treatment.
METHODS: This prospective observational study investigated the changes in cytokines in snakebite patients and their potential for diagnosis.
RESULTS: Elevated pro-inflammatory cytokines IL-6 and TNF-α were observed in all snakebite patients compared to the healthy control group. While no significant disparities were observed in humoral immune response cytokines, there were significant differences in IFN-γ levels, with significantly higher IL-10 levels in patients bitten by cobras. Patients with TNF-α levels exceeding 3.02 pg/mL were more likely to have been bitten by a cobra.
CONCLUSION: This study sheds light on the immune responses triggered by various venomous snakebites, emphasizing the potential of cytokine patterns for snakebite-type differentiation. Larger studies are needed to validate these findings for clinical use, ultimately improving snakebite diagnosis and treatment.