BMC molecular biology · 2007
Dynamic resolution of functionally related gene sets in response to acute heat stress.
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Szustakowski Joseph D, Kosinski Penelope A, Marrese Christine A, Lee Jee-Hyung, Elliman Stephen J, Nirmala Nanguneri, Kemp Daniel M
Аннотация
BACKGROUND: Using a gene clustering strategy we determined intracellular pathway relationships within skeletal myotubes in response to an acute heat stress stimuli. Following heat shock, the transcriptome was analyzed by microarray in a temporal fashion to characterize the dynamic relationship of signaling pathways.
RESULTS: Bioinformatics analyses exposed coordination of functionally-related gene sets, depicting mechanism-based responses to heat shock. Protein turnover-related pathways were significantly affected including protein folding, pre-mRNA processing, mRNA splicing, proteolysis and proteasome-related pathways. Many responses were transient, tending to normalize within 24 hours.
CONCLUSION: In summary, we show that the transcriptional response to acute cell stress is largely transient and proteosome-centric.
RESULTS: Bioinformatics analyses exposed coordination of functionally-related gene sets, depicting mechanism-based responses to heat shock. Protein turnover-related pathways were significantly affected including protein folding, pre-mRNA processing, mRNA splicing, proteolysis and proteasome-related pathways. Many responses were transient, tending to normalize within 24 hours.
CONCLUSION: In summary, we show that the transcriptional response to acute cell stress is largely transient and proteosome-centric.