Neural tube defects in New South Wales: management and preventive policies, 1965-1980.

This paper reviews the results of the programme of antenatal testing and selective termination of fetuses with anencephaly and spina bifida in New South Wales over the last eight years. It discusses the problems associated with pregnancy screening, with reference to those involved in selection for treatment of newborn infants with spina bifida. The incidence of neural tube defects has been declining, and this, although possibly the result of early termination of affected fetuses, may have its basis in a worldwide trend. Preventive action based on a more precise understanding of aetiological factors will further decrease the incidence, thereby reducing the load of long-term handicapped survivors.