Медицинская библиотека · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2012

The association of a distinct plasma proteomic profile with the cervical high-grade squamous intraepithelial lesion of Uyghur women: a 2D liquid-phase chromatography/mass spectrometry study.

Guo Xia, Abliz Guzalnur, Reyimu Halidan, Zhao Feng, Kadeer Nafeisha, Matsidik Rukeya, Wu Guizhen, Abudula Abulizi

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To identify plasma protein biomarkers of cervical high-grade squamous intraepithelial lesion (HSIL) of Uyghur women by proteomics approach.

METHODS

Plasma protein samples of Uyghur women with HSIL and chronic cervicitis were analyzed with 2D HPLC followed by detection of target proteins with Linear Trap Quadrupole Mass Spectrometer (LTQ MS/MS).

RESULTS

We detected three upregulated and one downregulated protein peaks representing protein constituents distinguishing HSIL from controls by 2D HPLC, identified 31 target proteins by LTQ MS/MS. Further confirmed analysis with online software IPA® 8.7 and ELISA assay showed APOA1 and mTOR as potential biomarkers.

CONCLUSIONS

A distinct plasma proteomic profile may be associated with HSIL of Uyghur women.

Для цитирования: Guo Xia, Abliz Guzalnur, Reyimu Halidan, Zhao Feng, Kadeer Nafeisha, Matsidik Rukeya, Wu Guizhen, Abudula Abulizi. The association of a distinct plasma proteomic profile with the cervical high-grade squamous intraepithelial lesion of Uyghur women: a 2D liquid-phase chromatography/mass spectrometry study.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2012. DOI: 10.3109/1354750x.2012.673133.

Предметные рубрики MeSH

Adult Apolipoprotein A-I Asian People Biomarkers, Tumor Blood Proteins Brachial Plexus Neuritis Chromatography, Reverse-Phase Early Detection of Cancer Female Humans Intercellular Signaling Peptides and Proteins Middle Aged Placental Lactogen Proteomics TOR Serine-Threonine Kinases Tandem Mass Spectrometry Uterine Cervical Neoplasms Uterine Cervicitis Uterine Cervical Dysplasia

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