Diabetes and Femoral Fracture Patterns: A Nationwide Registry Study (1997-2021).

OBJECTIVE

To investigate the impact of diabetes on incidence rates (IRs), incidence rate ratios (IRRs), and site-specific fracture susceptibility of subtrochanteric/femoral shaft (ST/FS) and hip fractures.

RESEARCH DESIGN AND

METHODS

Using Danish registries, we estimated IRs, IRRs, and fracture site associations of ST/FS and hip fracture (1997-2021) in adults ≥65 years old with type 1 diabetes, with type 2 diabetes, and without diabetes.

RESULTS

IRRs were significantly higher in those with type 1 diabetes (ST/FS 2.53, P < 0.001; hip 2.17, P < 0.001) and type 2 diabetes (ST/FS 1.08, P = 0.002; hip 1.06, P = 0.008) compared with no diabetes. After age adjustment, only type 1 diabetes remained significantly increased. Adjusted analysis found both type 1 (odds ratio 1.14, P = 0.002) and type 2 (odds ratio 1.05, P = 0.008) diabetes to be significantly associated with higher odds of ST/FS compared with hip fractures.

CONCLUSIONS

Type 1 diabetes was associated with increased incidence of femoral fractures and slightly higher odds of ST/FS than hip fractures after adjustment.