Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2026
Clinical characteristics of Parvimonas micra bacteremia in Japan: A single-center case series and literature review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Inada Shugo, Kitagawa Hiroki, Omori Keitaro, Tadera Kayoko, Hara Toshinori, Kuhara Yuta, Omoto Takuji, Nomura Toshihito, Shigemoto Norifumi, Hattori Noboru, Ohge Hiroki
Аннотация
OBJECTIVES: Gram-positive anaerobic cocci (GPAC) account for 11-15% of anaerobic bacteremia. Parvimonas micra is one of the most commonly identified microorganisms in GPAC bacteremia. This study reviewed the clinical characteristics of P. micra bacteremia.
METHODS: We conducted a retrospective analysis of the records of 35 patients diagnosed with P. micra bacteremia at Hiroshima University Hospital between January 2011 and July 2024 and conducted a literature review, comparing our cases with previous reports.
RESULTS: The median patient age was 70 years, and 74% (26/35) were male. All had immunosuppressive conditions such as solid organ malignancy (49%, 17/35) and diabetes mellitus (34%, 12/35). Of the patients evaluated by a dentist, 96% (22/23) had periodontitis. The most common source of P. micra bacteremia was intra-abdominal infections (31%, 11/35), followed by dental (20%, 7/35), lower respiratory tract (20%, 7/35), and skin and soft tissue infections (14%, 5/35). The prevalence of dental infections was higher than that reported previously, but the distribution of other sources of infection was comparable. Of the patients with P. micra bacteremia, 57% (20/35) had polymicrobial infections, with members of the Streptococcus anginosus group being the most frequently identified co-pathogens (45%, 9/20). The 30-day mortality rate was 26% (9/35). All P. micra isolates showed low minimum inhibitory concentrations for β-lactam antibiotics.
CONCLUSION: Dental infection represented the second most frequent source of P. micra bacteremia, following intra-abdominal infection. In patients with P. micra bacteremia, clinicians should check for periodontitis and investigate the presence polymicrobial infections.
METHODS: We conducted a retrospective analysis of the records of 35 patients diagnosed with P. micra bacteremia at Hiroshima University Hospital between January 2011 and July 2024 and conducted a literature review, comparing our cases with previous reports.
RESULTS: The median patient age was 70 years, and 74% (26/35) were male. All had immunosuppressive conditions such as solid organ malignancy (49%, 17/35) and diabetes mellitus (34%, 12/35). Of the patients evaluated by a dentist, 96% (22/23) had periodontitis. The most common source of P. micra bacteremia was intra-abdominal infections (31%, 11/35), followed by dental (20%, 7/35), lower respiratory tract (20%, 7/35), and skin and soft tissue infections (14%, 5/35). The prevalence of dental infections was higher than that reported previously, but the distribution of other sources of infection was comparable. Of the patients with P. micra bacteremia, 57% (20/35) had polymicrobial infections, with members of the Streptococcus anginosus group being the most frequently identified co-pathogens (45%, 9/20). The 30-day mortality rate was 26% (9/35). All P. micra isolates showed low minimum inhibitory concentrations for β-lactam antibiotics.
CONCLUSION: Dental infection represented the second most frequent source of P. micra bacteremia, following intra-abdominal infection. In patients with P. micra bacteremia, clinicians should check for periodontitis and investigate the presence polymicrobial infections.