Indoramin in the hypertensive patient with concomitant disease: clinical experience.

Hypertension has a high prevalence in most countries, so it is to be expected that hypertension will be found together with other common diseases in many patients. The association between the hypertension and the concomitant disease may be causal or casual. The presence of some other disease in the hypertensive patient often places severe restraints on the choice of antihypertensive therapy. Indoramin, an alpha adrenoreceptor antagonist may be used without ill-effect in the therapy of hypertension in patients who also have chronic obstructive airways disease, congestive heart failure, mild renal failure, peripheral vascular disease, angina pectoris, and diabetes mellitus. In at least some of these patients, the use of beta adrenoreceptor blocking drugs or thiazide diuretics would be contraindicated. We do not know whether these advantages of indoramin are unique or whether they are a general property of all alpha-adrenoreceptor antagonists.