Journal of dentistry · 2026
Synergistic effect of sodium fluoride and encapsulated calcium lactate on dental erosion-abrasion prevention.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Bezerra Sávio José Cardoso, de Figueiredo Roberta Martins, Kairalla Cláudia A, Aoki Idalina Vieira, Hara Anderson T, Scaramucci Taís
Аннотация
OBJECTIVE: This study aimed to encapsulate calcium ions in mesoporous silica coated with a polyelectrolyte multilayer, incorporate these particles into an experimental mouthrinse, and evaluate their potential to control dental erosion-abrasion.
METHODS: Bovine enamel and dentin specimens were assigned to five groups: NaF (225 ppmF⁻), Ca²⁺ (encapsulated calcium), Ca+F (encapsulated calcium + NaF), F+Sn (225 ppmF⁻; 800 ppmSn²⁺), and Control (distilled water). Fluoride availability was measured using an ion-selective electrode. Specimens underwent a 5-day erosive-abrasive cycling model with citric acid challenges, brushing, and treatment with the assigned solutions. Surface loss (µm) was quantified by optical profilometry. Data were analyzed using one-way ANOVA and Tukey's test (α = 5 %).
RESULTS: Fluoride-containing solutions exhibited the expected ion availability, and no interaction between fluoride and encapsulated calcium was detected. In enamel, only F+Sn (4.81±0.13) significantly reduced surface loss compared to the Control (9.91±0.06) (p < 0.001). In dentin, Ca+F (10.39±0.48) significantly reduced surface loss relative to the Control (12.07±1.33) (p = 0.014) and did not differ from F+Sn (9.10±1.29) (p = 0.095). NaF and Ca alone showed no significant protective effect for either substrate.
CONCLUSIONS: Mesoporous silica loaded with calcium, when combined with NaF, provided protection against dentin erosive wear but did not reduce enamel loss. Tin-containing formulations remained the most effective option for enamel.
CLINICAL SIGNIFICANCE: A fluoride mouthrinse containing calcium encapsulated in mesoporous silica demonstrated protective potential for dentin under erosive-abrasive conditions, offering a promising tin-free alternative for individuals with dentin exposure requiring management of erosive tooth wear.
METHODS: Bovine enamel and dentin specimens were assigned to five groups: NaF (225 ppmF⁻), Ca²⁺ (encapsulated calcium), Ca+F (encapsulated calcium + NaF), F+Sn (225 ppmF⁻; 800 ppmSn²⁺), and Control (distilled water). Fluoride availability was measured using an ion-selective electrode. Specimens underwent a 5-day erosive-abrasive cycling model with citric acid challenges, brushing, and treatment with the assigned solutions. Surface loss (µm) was quantified by optical profilometry. Data were analyzed using one-way ANOVA and Tukey's test (α = 5 %).
RESULTS: Fluoride-containing solutions exhibited the expected ion availability, and no interaction between fluoride and encapsulated calcium was detected. In enamel, only F+Sn (4.81±0.13) significantly reduced surface loss compared to the Control (9.91±0.06) (p < 0.001). In dentin, Ca+F (10.39±0.48) significantly reduced surface loss relative to the Control (12.07±1.33) (p = 0.014) and did not differ from F+Sn (9.10±1.29) (p = 0.095). NaF and Ca alone showed no significant protective effect for either substrate.
CONCLUSIONS: Mesoporous silica loaded with calcium, when combined with NaF, provided protection against dentin erosive wear but did not reduce enamel loss. Tin-containing formulations remained the most effective option for enamel.
CLINICAL SIGNIFICANCE: A fluoride mouthrinse containing calcium encapsulated in mesoporous silica demonstrated protective potential for dentin under erosive-abrasive conditions, offering a promising tin-free alternative for individuals with dentin exposure requiring management of erosive tooth wear.