The Pediatric infectious disease journal · 2025
Streptococcus canis Rapidly Progressive and Fatal Neonatal Sepsis in a Term Infant.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Saleh Ezzeldin, O'Neal Ashley, Torres Eunice, Vargas Laura, Rodriguez Marcela, Chaudhary Subhash
Аннотация
BACKGROUND: Streptococcus canis ( S. canis ), belonging to β-hemolytic group G streptococci, is increasingly reported to cause sepsis and severe infections in adults with comorbidities but is rarely reported in children.
METHODS: We describe a case of S. canis neonatal sepsis in a term infant with a rapidly fatal outcome. We reviewed the literature on neonatal infections due to all group G streptococci including S. canis .
RESULTS: We identified 10 articles describing 19 cases of neonatal sepsis due to group G streptococcus, of which only 3 cases were identified at the species level. Most patients presented in the first week of life with neonatal sepsis with bacteremia present in 90% of cases. Among the patients, gestational age ranged from 31 to 42 weeks. Prematurity was reported in 35% of the patients. All patients were treated with β-lactams with or without aminoglycosides. Mortality was 26%.
CONCLUSIONS: S. canis infection is rare in the setting of neonatal sepsis; however, it can lead to high morbidity and mortality. It is imperative to promptly administer empiric antibiotics for critically ill neonates until neonatal sepsis is ruled out. β-lactams provide adequate coverage against S. canis . Further epidemiological and clinical studies focusing on S. canis are needed to fully understand the transmission and disease burden of this pathogen in neonates.
METHODS: We describe a case of S. canis neonatal sepsis in a term infant with a rapidly fatal outcome. We reviewed the literature on neonatal infections due to all group G streptococci including S. canis .
RESULTS: We identified 10 articles describing 19 cases of neonatal sepsis due to group G streptococcus, of which only 3 cases were identified at the species level. Most patients presented in the first week of life with neonatal sepsis with bacteremia present in 90% of cases. Among the patients, gestational age ranged from 31 to 42 weeks. Prematurity was reported in 35% of the patients. All patients were treated with β-lactams with or without aminoglycosides. Mortality was 26%.
CONCLUSIONS: S. canis infection is rare in the setting of neonatal sepsis; however, it can lead to high morbidity and mortality. It is imperative to promptly administer empiric antibiotics for critically ill neonates until neonatal sepsis is ruled out. β-lactams provide adequate coverage against S. canis . Further epidemiological and clinical studies focusing on S. canis are needed to fully understand the transmission and disease burden of this pathogen in neonates.