In-hospital outcomes and temporal analysis of paralyzed patients with acute myocardial infarction undergoing percutaneous coronary intervention.

This study aimed to explore the association between two major etiologies of paralysis and the in-hospital outcomes of patients with acute myocardial infarction (AMI) who had undergone percutaneous coronary intervention (PCI). We retrieved AMI patients undergoing PCI from the National Inpatient Sample (2003-2015) and divided them into without paralysis, spinal cord injury (SCI) paralysis, and stroke paralysis. Paralysis' impact on hospital outcomes was explored using multivariate regression. Interaction analysis was used to investigate the sex differences. We observed the temporal trends of in-hospital outcomes from 2003 to 2015 by paralysis etiology. A total of 2,151,994 AMI cases were identified, with 6,711 SCI paralysis and 8,322 stroke paralysis. Compared to patients without paralysis, patients with SCI but not stroke paralysis had increased rates of in-hospital mortality (odds ratio [OR]: 2.8, 95% confidence interval [CI]: 1.9-3.9), cardiogenic shock (OR: 2.4, 95% CI: 1.8-3.3). Furthermore, this positive association between SCI and in-hospital adverse outcomes is more significant in females than males. In conclusion, SCI paralysis is associated with an increased risk of in-hospital mortality, cardiogenic shock in patients with AMI undergoing PCI, especially in females. These disparities lasted from 2003 to 2015.