Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2026
The Simplified Pregnancy Risk Score (SPRS): Personalized Preeclampsia Risk Stratification for Living Kidney Donors.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
El Hennawy Hany M, Safar Omar, Aboelsamh Ghaleb, Sadagah Laila Fahad, El Hennawy Menna, Balla Mohamed Elamien, Khedr Abdullah, Ibrahim Mona, Jaber Tariq, Tawahri Ibrahim
Аннотация
OBJECTIVES: Pregnancy after living kidney donation is associated with increased risk of preeclampsia and other hypertensive disorders; however, clinical practice and a standardized approach remain unclear. We performed a systematic review and meta-analysis to provide updated risk estimates for adverse pregnancy outcomes after living kidney donation, to allow development and preliminary assessment of the Simplified Pregnancy Risk Score, a structured framework for individualized risk stratification.
MATERIALS AND METHODS: We followed PRISMA guidelines and searched PubMed, Scopus, Web of Science, and the Cochrane Library through August 2023 to include studies on maternal and fetal outcomes in pregnancies after living kidney donation. We used random-effects models to pool odds ratios and calculate absolute risk differences. We used subgroup and regression analyses to identify key risk modifiers that informed the development of the points-based Simplified Pregnancy Risk Score.
RESULTS: Our search identified 15 studies encompassing 4200 pregnancies. Preeclampsia (pooled incidence 7.2%; odds ratio = 2.86; 95% CI, 1.62-5.05; absolute risk difference +4.7% ) and gestational hypertension (odds ratio = 2.53, 95% CI, 1.11-5.74)were significantly increased in donors compared with nondonors. Risk of preterm birth was modestly increased (odds ratio = 1.32; 95% CI, 1.01-1.74). Subgroup analyses identified clinically relevant effect modifiers: donors aged ≥35 years had higher odds of preeclampsia than younger donors, and a donation-to-conception interval of <2 years was associated with increased risk of preterm birth. The Simplified Pregnancy Risk Score integrated 8 evidence-based factors into a simple points-based system, categorizing donors as low (0-2 points), moderate (3-5 points), or high risk (≥6 points).
CONCLUSIONS: The Simplified Pregnancy Risk Score represents the first structured, evidence-informed framework designed to support individualized pre-conception counseling and risk-aware antenatal management in kidney donors. Although formal validation is required, this system addresses a critical translational gap by converting population-level evidence into actionable clinical risk stratification.
MATERIALS AND METHODS: We followed PRISMA guidelines and searched PubMed, Scopus, Web of Science, and the Cochrane Library through August 2023 to include studies on maternal and fetal outcomes in pregnancies after living kidney donation. We used random-effects models to pool odds ratios and calculate absolute risk differences. We used subgroup and regression analyses to identify key risk modifiers that informed the development of the points-based Simplified Pregnancy Risk Score.
RESULTS: Our search identified 15 studies encompassing 4200 pregnancies. Preeclampsia (pooled incidence 7.2%; odds ratio = 2.86; 95% CI, 1.62-5.05; absolute risk difference +4.7% ) and gestational hypertension (odds ratio = 2.53, 95% CI, 1.11-5.74)were significantly increased in donors compared with nondonors. Risk of preterm birth was modestly increased (odds ratio = 1.32; 95% CI, 1.01-1.74). Subgroup analyses identified clinically relevant effect modifiers: donors aged ≥35 years had higher odds of preeclampsia than younger donors, and a donation-to-conception interval of <2 years was associated with increased risk of preterm birth. The Simplified Pregnancy Risk Score integrated 8 evidence-based factors into a simple points-based system, categorizing donors as low (0-2 points), moderate (3-5 points), or high risk (≥6 points).
CONCLUSIONS: The Simplified Pregnancy Risk Score represents the first structured, evidence-informed framework designed to support individualized pre-conception counseling and risk-aware antenatal management in kidney donors. Although formal validation is required, this system addresses a critical translational gap by converting population-level evidence into actionable clinical risk stratification.