Fertility and sterility · 2003
Effect of oral contraceptives and intrauterine devices on midcycle myometrial contractions.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Maslow Kenny D, Lyons Edward A
Аннотация
OBJECTIVE: To determine the effects of oral contraceptives and intrauterine devices (IUDs) on midcycle myometrial contractions.
DESIGN: Prospective cohort study.
SETTING: Academic tertiary care center.
PATIENT(S): Thirty four patients who received oral contraceptives, 20 patients with an IUD, 28 controls, and 6 patients who were evaluated before and after oral contraceptive use.
INTERVENTION(S): All groups underwent endovaginal ultrasonography to visualize myometrial contractions at midcycle.
MAIN OUTCOME MEASURE(S): Contractions were analyzed for direction, frequency, amplitude, and distance traveled.
RESULT(S): Fifty percent of women taking oral contraceptives had no contractions, whereas all controls had contractions. Women taking oral contraceptives also had decreased frequency, amplitude, and distance traveled of contractions compared with controls. Women evaluated before and after taking oral contraceptives had decreased frequency, amplitude, and distance traveled of contractions. Women with an IUD had significantly more asymmetrical uncoordinated contractions, with decreased frequency and distance traveled, compared with controls.
CONCLUSION(S): Oral contraceptives dramatically suppressed midcycle contractility. Since the normal midcycle peak of estrogen is suppressed by oral contraceptives, these contractions may be regulated by cyclic estrogen and progesterone. Uncoordinated contractions in IUD bearing women indicate that the foreign body reaction of the IUD affects the normal physiology of these contractions.
DESIGN: Prospective cohort study.
SETTING: Academic tertiary care center.
PATIENT(S): Thirty four patients who received oral contraceptives, 20 patients with an IUD, 28 controls, and 6 patients who were evaluated before and after oral contraceptive use.
INTERVENTION(S): All groups underwent endovaginal ultrasonography to visualize myometrial contractions at midcycle.
MAIN OUTCOME MEASURE(S): Contractions were analyzed for direction, frequency, amplitude, and distance traveled.
RESULT(S): Fifty percent of women taking oral contraceptives had no contractions, whereas all controls had contractions. Women taking oral contraceptives also had decreased frequency, amplitude, and distance traveled of contractions compared with controls. Women evaluated before and after taking oral contraceptives had decreased frequency, amplitude, and distance traveled of contractions. Women with an IUD had significantly more asymmetrical uncoordinated contractions, with decreased frequency and distance traveled, compared with controls.
CONCLUSION(S): Oral contraceptives dramatically suppressed midcycle contractility. Since the normal midcycle peak of estrogen is suppressed by oral contraceptives, these contractions may be regulated by cyclic estrogen and progesterone. Uncoordinated contractions in IUD bearing women indicate that the foreign body reaction of the IUD affects the normal physiology of these contractions.