Potential of Vaginal Microbiota Transplantation (VMT) in Endometritis Management.

PROBLEM: Endometritis is an inflammatory disorder often associated with microbial imbalance. Common treatments, such as antibiotics, may lead to drug resistance and do not ensure long-term microbial stability.

METHOD OF STUDY: This mini review examines vaginal microbiota transplantation (VMT) as a novel approach to the management of endometritis. VMT involves the transfer of healthy microbiota from a donor to restore microbial balance in the recipient.

RESULTS

VMT helps maintain vaginal acidity and inhibit pathogenic bacteria by restoring the dominant Lactobacillus spp. One of its key mechanisms is inhibiting the NF-κB signaling pathway, which leads to a decrease in inflammatory cytokines such as IL-6, IL-1β, and TNF-α. This reduces tissue inflammation and improves healing. VMT is also more biocompatible than antibiotics and can be more effective in combination with other treatments.

CONCLUSIONS

VMT is a promising noninvasive approach to the treatment of endometritis, with safety and microbial benefits. However, further studies and standardization of methods are needed to confirm its clinical utility.