Journal of spine surgery (Hong Kong) · 2026
ABM/P-15-enhanced bone graft in oncologic cervical spine reconstruction: two case reports and narrative discussion.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Rodrigues Neto Henrique Ribeiro, Cardahi Federico, Mozafari-Lorestani Kaveh, Kubik William, Montreuil Julien, Bozzo Anthony, Aoude Ahmed
Аннотация
BACKGROUND: Bone consolidation in musculoskeletal oncology is challenging after pathological fracture, radiotherapy, repeated surgery, extensive reconstruction, or compromised vascularity. Successful healing also requires segmental mechanical stability. Anorganic bone mineral/P-15 (ABM/P-15) bone grafts provide an osteoconductive mineral scaffold with a synthetic collagen-mimetic peptide surface, but their use in oncologic cervical spine reconstruction remains sparsely described.
CASE DESCRIPTION: At the McGill University Health Centre, a tertiary referral center, we report two complex cervical oncologic reconstructions in which ABM/P-15 was used as one component of multicomponent fusion constructs. A young adult male with metastatic solitary fibrous tumor, prior radiotherapy, upper cervical nonunion, and pathologic fracture underwent revision occiput-to-T2 fusion with local autograft and ABM/P-15. A young adult female with recurrent cervical chordoma after prior resection and proton-beam radiotherapy underwent combined anterior and posterior tumor resection, instrumentation, and fibular graft reconstruction augmented with ABM/P-15. In both cases, rigid reconstruction plus adjunctive grafting was followed by CT and radiographic evidence of bridging bone or host-graft incorporation without implant loosening or pseudoarthrosis at approximately 12 months. Standardized Visual Analog Scale (VAS)/Numeric Rating Scale (NRS) and Neck Disability Index (NDI) scores were not collected.
CONCLUSIONS: These two cases document radiographic fusion after complex oncologic cervical reconstructions in which ABM/P-15 was used as an adjunct. The perceived rationale was to provide an osteoconductive, collagen-mimetic surface in compromised host biology, but these cases do not establish that ABM/P-15 independently caused fusion or improved oncologic safety. The findings should be interpreted as descriptive and hypothesis-generating.
CASE DESCRIPTION: At the McGill University Health Centre, a tertiary referral center, we report two complex cervical oncologic reconstructions in which ABM/P-15 was used as one component of multicomponent fusion constructs. A young adult male with metastatic solitary fibrous tumor, prior radiotherapy, upper cervical nonunion, and pathologic fracture underwent revision occiput-to-T2 fusion with local autograft and ABM/P-15. A young adult female with recurrent cervical chordoma after prior resection and proton-beam radiotherapy underwent combined anterior and posterior tumor resection, instrumentation, and fibular graft reconstruction augmented with ABM/P-15. In both cases, rigid reconstruction plus adjunctive grafting was followed by CT and radiographic evidence of bridging bone or host-graft incorporation without implant loosening or pseudoarthrosis at approximately 12 months. Standardized Visual Analog Scale (VAS)/Numeric Rating Scale (NRS) and Neck Disability Index (NDI) scores were not collected.
CONCLUSIONS: These two cases document radiographic fusion after complex oncologic cervical reconstructions in which ABM/P-15 was used as an adjunct. The perceived rationale was to provide an osteoconductive, collagen-mimetic surface in compromised host biology, but these cases do not establish that ABM/P-15 independently caused fusion or improved oncologic safety. The findings should be interpreted as descriptive and hypothesis-generating.