Journal of agricultural and food chemistry · 2025
Pou2f3 Modulates Mosquito Host-Seeking Behavior by Regulating Skin Microbiota and Their Production of Volatiles: Implications for Eco-Friendly Pest Control Strategies.
СтатьяНазвание и аннотация: Перевод в очереди
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Wang Hui, Qian Ruixi, Wang Yuxiang, Li Lanxi, Wu Wenxuan, Chen Yunxuan, Li Wenqing, Wijewardana Chanuka Nisalanka, Zhou Yinghui, Padde John Roberts, Zhang Donghui, Hou Min, Xu Zhipeng, Ji MinJun, Chen Lu, Chen Lin
Аннотация
Skin microbiota-derived volatile metabolites are critical for mosquito host-seeking and disease transmission. Similar volatile organic compounds (VOCs)-mediated mechanisms may apply to agricultural pests (e.g., aphids, whiteflies). We demonstrate that Pou2f3, a skin-enriched transcription factor, regulates β-defensin1 expression, shaping microbiota composition and volatile production. Pou2f3-deficient mice exhibited increased Staphylococcus abundance and elevated 1-methoxy-2-propanol levels, enhancing attraction in Culex and Aedes mosquitoes. This VOC, alongside other microbiota-derived compounds, could inspire targeted attractants for eco-friendly pest control via species-specific lures in integrated pest management (IPM). By bridging medical entomology and agricultural chemistry, this work advances sustainable solutions against vector-borne diseases and agricultural pests through precision chemical ecology strategies.