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DOI 10.3349/ymj.2014.55.6.1562

Медицинская библиотека · Yonsei medical journal · 2014

Coxsackievirus B infection is highly related with missed abortion in Korea.

Hwang Jung Hye, Kim Jeong Wook, Hwang Ji Young, Lee Kyung Min, Shim Hye Min, Bae Young Kyung, Paik Seung Sam, Park Hosun

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

PURPOSE: This study investigated the possible relationship between viral infection and first trimester pregnancy loss.

MATERIALS AND

METHODS

A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.

RESULTS

Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.

CONCLUSION

The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.

Для цитирования: Hwang Jung Hye, Kim Jeong Wook, Hwang Ji Young, Lee Kyung Min, Shim Hye Min, Bae Young Kyung, Paik Seung Sam, Park Hosun. Coxsackievirus B infection is highly related with missed abortion in Korea.. Yonsei medical journal. 2014. DOI: 10.3349/ymj.2014.55.6.1562.

Предметные рубрики MeSH

Abortion, MissedAdultCoxsackievirus InfectionsEnterovirus B, HumanFemaleHumansImmunohistochemistryPlacentaPregnancyPregnancy Complications, InfectiousPregnancy Trimester, FirstPrevalenceProspective StudiesRepublic of KoreaReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNAUterus
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