Base-mediated synthesis of cyclic dithiocarbamates from 1-amino-3-chloropropan-2-ol derivatives and carbon disulfide.

An efficient method for the preparation of six-membered cyclic dithiocarbamates is described, in which triethylamine effectively promotes the reaction of 1-amino-3-chloropropan-2-ol derivatives with carbon disulfide. On the basis of the experimental and theoretical studies, a reaction mechanism is proposed to explain the difference between the present reaction and our previously reported carbon dioxide fixation.