European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006
Addition of a macrolide to a ss-lactam in bacteremic pneumococcal pneumonia.
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Dwyer R, Ortqvist A, Aufwerber E, Henriques Normark B, Marrie T J, Mufson M A, Torres A, Woodhead M A, Alenius M, Kalin M
Аннотация
In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a ss-lactam +/- a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/ss-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age >65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)>8.