Nucleosides, nucleotides & nucleic acids · 2026
LINC00885 suppresses gastric cancer progression by sponging miR-320c and serves as a diagnostic biomarker.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ding Suyan, Zhu Buluan, Sun Tiantian, Qu Lili
Аннотация
BACKGROUND: Long non-coding RNAs (lncRNAs) perform critical functions in tumorigenesis and the development of malignancy. Dysregulation of LINC00885 has been associated with intricate biological processes in diverse cancer types. However, the functional significance of LINC00885 in gastric cancer (GC) and the mechanistic underpinnings governing its activity have yet to be thoroughly investigated.
METHODS: LINC00885 expression levels were assessed in serum specimens obtained from both healthy donors and GC patients, as well as across various GC cell lines, employing quantitative reverse transcription polymerase chain reaction (RT-qPCR). The diagnostic efficacy of LINC00885 was determined through receiver operating characteristic (ROC) curve analysis. Cellular functions (proliferation, migration, invasion) and the nature of miRNA interactions were elucidated via functional assays and rescue experiments.
RESULTS: LINC00885 expression was markedly reduced in GC and demonstrated the capacity to differentiate GC patients from healthy controls. Based on the median serum LINC00885 expression level in 218 gastric cancer patients, cases were categorized into high- and low-expression groups. Low serum LINC00885 levels were significantly associated with larger tumor size (p = 0.044) and advanced TNM stage (p = 0.022), but not with other clinicopathological parameters. Ectopic expression of LINC00885 inhibited the proliferative, migratory, and invasive capacities of GC cells. LINC00885 was demonstrated to bind directly to miR-320c and modulate GC cellular behavior. Mechanistically, the tumor-suppressive impact of LINC00885 during GC progression is likely mediated by its function as a competitive endogenous RNA (ceRNA), sequestering miR-320c.
CONCLUSION: LINC00885 exhibits potential diagnostic value and represents a promising therapeutic target for GC.
METHODS: LINC00885 expression levels were assessed in serum specimens obtained from both healthy donors and GC patients, as well as across various GC cell lines, employing quantitative reverse transcription polymerase chain reaction (RT-qPCR). The diagnostic efficacy of LINC00885 was determined through receiver operating characteristic (ROC) curve analysis. Cellular functions (proliferation, migration, invasion) and the nature of miRNA interactions were elucidated via functional assays and rescue experiments.
RESULTS: LINC00885 expression was markedly reduced in GC and demonstrated the capacity to differentiate GC patients from healthy controls. Based on the median serum LINC00885 expression level in 218 gastric cancer patients, cases were categorized into high- and low-expression groups. Low serum LINC00885 levels were significantly associated with larger tumor size (p = 0.044) and advanced TNM stage (p = 0.022), but not with other clinicopathological parameters. Ectopic expression of LINC00885 inhibited the proliferative, migratory, and invasive capacities of GC cells. LINC00885 was demonstrated to bind directly to miR-320c and modulate GC cellular behavior. Mechanistically, the tumor-suppressive impact of LINC00885 during GC progression is likely mediated by its function as a competitive endogenous RNA (ceRNA), sequestering miR-320c.
CONCLUSION: LINC00885 exhibits potential diagnostic value and represents a promising therapeutic target for GC.