Analysis of Blood Components of Xiangju Tablets Based on UPLC-QTOF-MS/MS and Network Pharmacology.

Based on serum pharmacochemistry and network pharmacology, the pharmacodynamic material basis and mechanism of Xiangju tablets (XJPs) in the treatment of rhinitis and sinusitis were discussed. UPLC-QTOF-MS/MS technology combined with Compound Discover 3.0 was used to analyze and identify the in vivo and in vitro components of XJP. The blood components of XJP were obtained. The protein interaction network was constructed by network pharmacology, combined with GO functional analysis and KEGG enrichment analysis to reveal the key active components and potential mechanism of XJP in the treatment of rhinitis and sinusitis. A total of 423 compounds were identified in XJP, of which 41 were blood components, including gallic acid, chlorogenic acid, caffeic acid, epicatechin, rutin, rosmarinic acid, and linarin. These active components may regulate PI3K-Akt, MAPK, Ras, Rap1, and other signaling pathways through key targets such as GAPDH, MAPK3, SRC, AKT1, CASP3, and IL6. XJP exerts the effect of treating rhinitis and sinusitis through multicomponent-multitarget-multipathway. This study provides a reference for the study of the mechanism of XJP in the treatment of rhinitis and sinusitis and provides new ideas for the development of new dosage forms for targeted treatment of rhinitis and sinusitis.