EXPRESSION OF CONCERN: Small Interference RNA Targeting Heat-Shock Protein 27 Inhibits the Growth of Prostatic Cell Lines and Induces Apoptosis via Caspase-3 Activation In Vitro.

P. Rocchi, P. Jugpal, A. So, S. Sinneman, S. Ettinger, L. Fazli, C. Nelson and M. Gleave, "Small Interference RNA Targeting Heat-Shock Protein 27 Inhibits the Growth of Prostatic Cell Lines and Induces Apoptosis via Caspase-3 Activation In Vitro," BJU International 98, no. 5 (2006): 1082-1089, https://doi.org/10.1111/j.1464-410X.2006.06425.x. This Expression of Concern is for the above article, published online on 09 October 2006 in Wiley Online Library (wileyonlinelibrary.com), and its correction https://doi.org/10.1111/bju.70026. It has been issued by agreement between the journal Editor-in-Chief, Freddie Hamdy; and John Wiley & Sons Ltd. UK. The Expression of Concern has been issued following concerns raised by a third party. Following an investigation, it was confirmed that the blots in Fig. 2 were taken from earlier publications and were produced using siRNA sequences that differ from those reported in this study. As the figure does not correspond to the experimental conditions described in the study, Fig. 2 cannot be considered a valid representation of the results reported, contrary to the authors' correction. The author's institution was contacted regarding this matter, but no response has been received. As the concerns remain unresolved, the journal has decided to issue an Expression of Concern to alert readers to these issues.