Management of Severe Menorrhagia in an Adolescent with Glanzmann Thrombasthenia: A Case Report and Treatment Approach.

This case report describes the management of severe menorrhagia in a 13-year-old girl diagnosed with Glanzmann thrombasthenia (GT), a rare inherited platelet disorder. The patient presented with excessive menstrual bleeding, leading to hypovolemic shock. Diagnosis was confirmed by flow cytometry and genetic testing. Treatment included blood product transfusions, tranexamic acid, and ormeloxifene administration. This case required complex management beyond typical hypovolemic shock protocols because of the underlying platelet dysfunction. Long-term management involves oral contraceptives, desmopressin, and counseling on bleeding precautions. This case highlights the challenges in managing GT, emphasizing the need for a multidisciplinary approach, tailored treatment strategies, and consideration of future therapeutic options such as hematopoietic stem cell transplantation and gene therapy. The report also discusses the rationale behind the treatment choices, including the use of ormeloxifene and cryoprecipitate, and compares the management approach to established guidelines. Additionally, it addresses the importance of genetic counseling, patient education, and ongoing research in improving outcomes for patients with GT.