Oral diseases · 2026
Evaluation of the Volatile Sulfur Compound Stability in Breath Samples for Halitosis Remote Diagnosis.
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Militsi Eirini, Reingewirtz Yves, Séverac François, Huck Olivier, Gegout Pierre-Yves
Аннотация
BACKGROUND: This study assessed the feasibility of remote halitosis diagnosis by evaluating VSC stability over 7 days and their association with periodontal parameters.
METHODS: One hundred adult patients attending a periodontal examination were included. Oral gas samples were collected using plastic syringes and analyzed by gas chromatography (OralChroma) at baseline (D0) and after 7 days of storage at room temperature (D7). Hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and dimethyl sulfide ((CH3)2S) were quantified. Periodontal parameters were recorded. Correlations and agreement analyses were performed.
RESULTS: At D0, 64% and 31% of patients were classified as having halitosis using thresholds of > 120 ppb and > 300 ppb, respectively. Mean VSC concentrations were 10.2 (33.1) ppb for H2S, 208.3 (443.2) ppb for CH3SH, and 79 (166) ppb for (CH3)2S, and increased after 7 days of storage for all compounds except H2S. Only (CH3)2S showed a significant correlation between D0 and D7 measurements. Agreement between halitosis diagnoses at D0 and D7 was poor for both thresholds (Cohen's kappa < 0.2). Associations between VSC levels and periodontal parameters were weak.
CONCLUSION: Delayed analysis of oral gas samples significantly altered VSC measurements limiting their reliability for remote halitosis diagnosis. Periodontal parameters were not strongly associated with VSC levels.
METHODS: One hundred adult patients attending a periodontal examination were included. Oral gas samples were collected using plastic syringes and analyzed by gas chromatography (OralChroma) at baseline (D0) and after 7 days of storage at room temperature (D7). Hydrogen sulfide (H2S), methyl mercaptan (CH3SH), and dimethyl sulfide ((CH3)2S) were quantified. Periodontal parameters were recorded. Correlations and agreement analyses were performed.
RESULTS: At D0, 64% and 31% of patients were classified as having halitosis using thresholds of > 120 ppb and > 300 ppb, respectively. Mean VSC concentrations were 10.2 (33.1) ppb for H2S, 208.3 (443.2) ppb for CH3SH, and 79 (166) ppb for (CH3)2S, and increased after 7 days of storage for all compounds except H2S. Only (CH3)2S showed a significant correlation between D0 and D7 measurements. Agreement between halitosis diagnoses at D0 and D7 was poor for both thresholds (Cohen's kappa < 0.2). Associations between VSC levels and periodontal parameters were weak.
CONCLUSION: Delayed analysis of oral gas samples significantly altered VSC measurements limiting their reliability for remote halitosis diagnosis. Periodontal parameters were not strongly associated with VSC levels.