Dual Photoredox/NHC Catalysis with a Renewable Feedstock: Accessing Quaternary γ-Amino Ketones from Proline.

A mild and efficient dual photoredox/NHC catalytic system is developed for the synthesis of γ-amino ketones from naturally sourced proline derivatives, alkenes, and aryl carboxylic acids. This three-component radical coupling constructs two new C-C bonds in a single operation, affording a range of quaternary γ-amino ketones in moderate to excellent yields with broad substrate scope and good functional group tolerance. The reaction operates under mild, room-temperature conditions and uses renewable proline feedstocks. Gram-scale synthesis further demonstrates the scalability and practicality of this green protocol.