<sc>d</sc>-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI).
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Dinicola Simona, Unfer Vittorio, Soulage Christophe O, Yap-Garcia Maria Isidora Margarita, Bevilacqua Arturo, Benvenga Salvatore, Barbaro Daniele, Wdowiak Artur, Nordio Maurizio, Dewailly Didier, Appetecchia Marialuisa, Aragona Cesare, Espinola Maria Salomè Bezerra, Bizzarri Mariano, Cavalli Pietro, Colao Annamaria, D'Anna Rosario, Vazquez-Levin Mónica Hebe, Hernàndez Marin Imelda, Kamenov Zdravko, Laganà Antonio Simone, Monastra Giovanni, Montanino Oliva Mario, Cenk Özay Ali, Pintaudi Basilio, Porcaro Giuseppina, Pustotina Olga, Pkhaladze Lali, Prapas Nikos, Roseff Scott, Salehpour Saghar, Stringaro Annarita, Tugushev Marat, Unfer Virginia, Vucenik Ivana, Facchinetti Fabio
Аннотация
OBJECTIVES: This perspective seeks to explore the mechanisms and functions of <sc>d</sc>-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation.
METHODS: A narrative review of all the relevant papers known to the authors was conducted.
OUTCOME: <sc>d</sc>-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue transdifferentiation. These different modes of action have potential applications in a variety of therapeutic fields, including PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health.
CONCLUSIONS: <sc>d</sc>-Chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between <sc>d</sc>-chiro-inositol and its isomer myo-inositol. The insulin-sensitizing activities of <sc>d</sc>-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study.