Perimenopausal symptom burden: implications for health, work and earlier clinical management.
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Rodríguez-Vidal Doris, Blümel Juan E, Chedraui Peter, Vallejo María S, Costa-Paiva Lucia, Gutiérrez-Crespo Hugo, Dextre Maribel, Díaz Karen, Elizalde-Cremonte Alejandra, Elizalde-Cremonte Santiago, Escalante-Gómez Carlos, Espinoza María T, García Ircania, Gómez-Tabares Gustavo, Matzumura-Kasano Juan, Meza Paolo, Monterrosa-Castro Álvaro, Ñañez Mónica, López Marcela, Ojeda Eliana, Rey Claudia, Valadares Ana Lucia Ribeiro, Rodrigues Marcio A H, Saavedra Javier, Salinas Carlos, Sosa Lida, Tserotas Konstantinos, Martín Margot Acuña-San, Aedo Sócrates, Aguirre Marcela S, Arteaga Eugenio, Ayala Félix, Bencosme Ascanio, Calle Andrés
Аннотация
METHOD: Secondary analysis included 1478 women aged 40-54 years from 12 Latin American countries, classified by age and menstrual status into four groups: age 40-44 years with regular cycles (reference), age 45-49 years with regular cycles, age 45-49 years with irregular cycles (perimenopause) and age 50-54 years with absent menses (early postmenopause). Symptoms, HRQoL, work-related outcomes and job satisfaction were assessed using validated instruments Multivariable logistic regression analyses were performed.
RESULTS: Symptom severity increased progressively across stages, with severe symptoms rising from 18.3% (reference group) to 50.6% in postmenopausal women (p < 0.001). Compared with the reference group, women with irregular cycles and those with absent menses had higher odds of severe symptoms (odds ratio [OR] 2.97 and 3.71), lower HRQoL (OR 1.62 and 1.97) and lower job satisfaction (OR 2.01 and 3.07), respectively. Menopausal stage was not independently associated with work-related quality of life.
CONCLUSION: Symptom burden and its impact on health and job satisfaction emerge before menopause and may inform earlier, stage-specific clinical guidance.