Comparison of seven Oxethazaine containing antacids available in the Indian market.

OBJECTIVE

This in-vitro study was designed to measure the quantity of acid neutralized by a suspension of a commercial antacid available in Indian markets at a labeled dose and to test the concept of the relative effectiveness of 7 different commercial antacids containing Oxethazaine.

METHODS

A simple back titration methodology was used to determine the acid neutralization capacity (ANC) of antacids.

RESULTS

It was observed that different antacids vary widely in their in vitro ANC. There was also a batch to batch variation noted for each brand of antacid. The analysis indicated that there was a significant difference of ANC in favor of AD versus other antacids studied.

CONCLUSION

Comparison of relative effectiveness indicates that AD has highest ANC in vitro amongst other antacids. However, the present study being in vitro, the effects of antacid may vary in vivo, as individual variations also contribute to the ultimate effectiveness of an antacid.