Medicine · 2018
Sarcoidosis of the medulla oblongata causing intractable hiccoughs and numbness of extremities: A case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Chen Xi-Yuan, Ren Zhuo-Chao, Huang Xiao-Jun
Аннотация
RATIONALE: Sarcoidosis is a multisystem disorder characterized by noncaseating granulomas. The nervous system is involved in 5 to 16% of the patients. However, neurosarcoidosis in the medulla oblongata presenting as hiccough is remarkably rare.
PATIENT CONCERN: A 55-year-old female was admitted to our hospital suffering from intractable hiccough and progressive numbness of extremities.
DIAGNOSIS: The MR imaging revealed a circumscribed mass lesion located on the medulla oblongata. The mass was hyperintense on T2-weighted images and enhanced homogeneously with gadolinium-diethylenetriamine penta-acetic acid. The cerebrospinal fluid analysis showed a moderately elevated protein content and a significant lymphocytosis 86.5%. Electrocardiogram (ECG) showed complete atrioventricular block. Bilateral supraclavicular, hilar, and mediastinal lymphadenopathy was diagnosed in a CT scan. Transbranchial needle aspiration biopsy revealed noncaseating granuloma consisting of epithelioid cells, lymphocytes, and rare multinucleated giant cells which was consistent with sarcoidosis. The diagnosis of multisystemic sarcoidosis was made.
INTERVENTIONS AND OUTCOMES: The patient underwent a permanent pacemaker insertion, and was successfully treated with corticosteroids.
LESSONS: It is important to consider neurosarcoidosis in the differential diagnosis of intramedullary lesion, since a right recognition may lead to appropriate treatment with steroids and avoid needlessly extensive surgery.
PATIENT CONCERN: A 55-year-old female was admitted to our hospital suffering from intractable hiccough and progressive numbness of extremities.
DIAGNOSIS: The MR imaging revealed a circumscribed mass lesion located on the medulla oblongata. The mass was hyperintense on T2-weighted images and enhanced homogeneously with gadolinium-diethylenetriamine penta-acetic acid. The cerebrospinal fluid analysis showed a moderately elevated protein content and a significant lymphocytosis 86.5%. Electrocardiogram (ECG) showed complete atrioventricular block. Bilateral supraclavicular, hilar, and mediastinal lymphadenopathy was diagnosed in a CT scan. Transbranchial needle aspiration biopsy revealed noncaseating granuloma consisting of epithelioid cells, lymphocytes, and rare multinucleated giant cells which was consistent with sarcoidosis. The diagnosis of multisystemic sarcoidosis was made.
INTERVENTIONS AND OUTCOMES: The patient underwent a permanent pacemaker insertion, and was successfully treated with corticosteroids.
LESSONS: It is important to consider neurosarcoidosis in the differential diagnosis of intramedullary lesion, since a right recognition may lead to appropriate treatment with steroids and avoid needlessly extensive surgery.