Neutrophil extracellular traps in cardiac hypertrophy: a KLF2 perspective.

PURPOSE: Open Reduction and Internal Fixation of the Femur (ORIF) is a surgical procedure which carries risk for complications including wound dehiscence and postoperative surgical site infections. This study aims to identify significant predictors of wound dehiscence, deep wound surgical site infection, organ/space surgical site infection within 30 days of ORIF for femoral shaft and subtrochanteric fractures.

METHODS

The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data registry was used to collect data on significant independent risk factors associated with the complications of interest within 30 days of operation. The ACS NSQIP was filtered to examine the outcome of dehiscence, superficial space, deep space, and organ space infections following ORIF. The following variables were tested for significance: Age, Sex, BMI, ASA classification, total operating time, anesthesia type, diabetes, preoperative steroid use, functional status, dialysis, cancer, hypertension requiring medication, preoperative albumin, preoperative platelets, and preoperative WBC.

RESULTS

The 30-day odds of wound dehiscence were significantly associated with higher BMI (p=0.004) and chronic steroid use (p=0.011). Significant predictors of deep incisional SSI included operative time (p<0.001), low preoperative albumin (p<0.001), high body mass index (p=0.026), general vs. neuraxial anesthesia (p=0.033), and preexisting renal dysfunction (p=0.04). Significant Predictors of organ/space infections included longer operative time (p<0.001) and lower preoperative albumin (p=0.016).

CONCLUSIONS

Elevated body mass index and prolonged operating time most consistently predicted the incidence of wound dehiscence and deep incisional, and organ space surgical site infections within 30 postoperative days of ORIF for femoral shaft and subtrochanteric fractures.