European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
Biomechanics of the Aortic Root and Ascending Aorta in Patients With Marfan Syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
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Eliathamby Daniella, Yap Hayley W Y, Elbatarny Malak, Cillero Rodrigo Antonio, Guruji Vrushali, Peterson Sachin, Alam Tanzia, Ouzounian Maral, Simmons Craig A, Chung Jennifer C-Y
Аннотация
OBJECTIVES: How Marfan syndrome (MFS) translates to alterations in ex vivo biomechanical properties of aortic tissue is not well defined. We aimed to characterize the biomechanical properties of the aortic root and ascending aorta in MFS and compare them to properties of normal, dissected, and non-MFS aneurysmal aortas.
METHODS: Biaxial tensile and delamination testing were performed on aortic tissue from patients with MFS (root = 10, ascending = 6), aneurysms with bicuspid aortic valves (BAVs) (root = 19, ascending = 88), aneurysms with tricuspid aortic valves (root = 25, ascending = 90), type A dissections (ascending = 17), and normal aortas (root = 12, ascending = 28). Differences in energy loss, low strain modulus, and delamination strength were investigated between patient groups.
RESULTS: In the aortic root, energy loss, low strain modulus, and delamination strength were not statistically different in MFS compared to all other groups. In the ascending aorta, delamination strength was lower in MFS than normal ascending aortas (31.9 ± 8.5 mN/mm vs 57.1 ± 17.0 mN/mm, P = 0.0003). The MFS group (0.071 ± 0.017) also had higher energy loss than normal (0.049 ± 0.011, P = 0.04), and lower low strain modulus (75.0 ± 11.0 kPa) than BAV (113.5 ± 33.6 kPa, P = 0.02).
CONCLUSIONS: The root and ascending aorta in MFS proved to have distinct biomechanical characteristics compared to normal aortas and other risk groups.
METHODS: Biaxial tensile and delamination testing were performed on aortic tissue from patients with MFS (root = 10, ascending = 6), aneurysms with bicuspid aortic valves (BAVs) (root = 19, ascending = 88), aneurysms with tricuspid aortic valves (root = 25, ascending = 90), type A dissections (ascending = 17), and normal aortas (root = 12, ascending = 28). Differences in energy loss, low strain modulus, and delamination strength were investigated between patient groups.
RESULTS: In the aortic root, energy loss, low strain modulus, and delamination strength were not statistically different in MFS compared to all other groups. In the ascending aorta, delamination strength was lower in MFS than normal ascending aortas (31.9 ± 8.5 mN/mm vs 57.1 ± 17.0 mN/mm, P = 0.0003). The MFS group (0.071 ± 0.017) also had higher energy loss than normal (0.049 ± 0.011, P = 0.04), and lower low strain modulus (75.0 ± 11.0 kPa) than BAV (113.5 ± 33.6 kPa, P = 0.02).
CONCLUSIONS: The root and ascending aorta in MFS proved to have distinct biomechanical characteristics compared to normal aortas and other risk groups.