Медицинская библиотека · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025

Epidemiology of non-central line-associated primary bloodstream infections in a network of Indian hospitals: A prospective surveillance study over 7 years (2017-2024).

Srivastava Ashish Kumar, Thakur Arpan Kumar, Singh Kumari Vandana, Parveen Rasna, Puraswani Mamta, Singh Parul, Chakrabarti Arunaloke, Rodrigues Camilla, Ray Pallab, Biswal Manisha, Taneja Neelam, Rudramurthy Shivaprakash M, Angrup Archana, Sehgal Inderpaul, Agarwal Ritesh, Wattal Chand, Venkatesh Vimala, Sethuraman Nandini, Bhattacharya Sanjay, Nag Vijaya Lakshmi, Tak Vibhor, Behera Bijayini, Hallur Vinaykumar, Balaji Veeraragavan, Ray Raja, Singh Sanjeev K, Mukhopadhyay Chiranjay, Michael Joy Sarojini, Fomda Bashir Ahmad, Karuna Tadepalli, Deotale Vijayshri, Prasad Amber, Majumder Tapan, Gupta Puneet Kumar, Padmaja Kanne, Bajpai Vijeta, Iravane Jyoti, Nath Reema, Gur Renu, Lyngdoh Nari M, Lyngdoh Clarissa, Devi Sheela, Malhotra Shalini, Gaind Rajni, Khuraijam Ranjana Devi, Sharma Rajni, Mullan Summaiya, Prakash John Antony Jude, Basu Shaoli, Paul Hema, Rupali Priscilla, Verma Sheetal, Thirunarayan M A, Raj Hirak Jyoti, Saxena Rushika, Rajdev Sangita, Goel Neeraj, Mukherjee Sudipta, Ramanathan Yamunadevi V, Chelliah Juliah, Mukherjee Satyam, Sonowal Aparna, Gupta Sharmila Sen, Verma Prachi, Muralidharan Jayashree, Yaddanapudi Lakshmi Narayana, Duseja Ajay, Jain Kajal, Dutta Usha, Bhattacharyya Parthasarathi, Mahapatra Ashoka, Som Tapas Kumar, Das Rashmi Ranjan, Tripathy Swagata, Mishra Tushar, Dey Anupam, Ke Vandana, Varma Muralidhar, Omar Balram Ji, Aggarwal Ankit, Baqal Sherish, Singh Langpoklakpam Chaoba, Gupta Neeraj, Bhatia Pradeep Kumar, Singh Kuldeep, Khera Daisy, Himanshu D, Gupta Sarika, Arshad Zia, Bhabor Ullash, Sarode Rahul, Pradhan Satyajit, Krishnamoorthi Sivanantham, Duggal Shalini Dewan, Kumar Rajender, Kaushal G P, Dabas Vikas, Kumar Subodh, Soni Kapil Dev, Sagar Sushma, Aggarwal Richa, Singh Gyaninder Pal, Bindra Ashish, Farooque Kamran, Walia Kamini, Mathur Purva

СтатьяМногоцентровое исследованиеПеревод в очереди

Аннотация

OBJECTIVES

To estimate the profile of non-central line-associated primary bloodstream infections (non-CLABSIs) in intensive care units of Indian hospitals participating in the standardized health-care-associated infection surveillance program.

METHODS

This is a multicentric, network-based, prospective surveillance study conducted in 180 individual intensive care units of 47 Indian tertiary care hospitals that were part of the Health-Care-Associated Infection Surveillance Network between May 2017 and April 2024. The non-CLABSIs were defined, monitored, and observed using standardized definitions and surveillance protocols (www.haisindia.com).

RESULTS

A total of 7092 laboratory-confirmed non-CLABSI cases and 30,74,954 patient days from 2017 to 2024 were recorded. The overall pooled non-CLABSI rate was 2.3 per 1000 patient days. Gram-negative isolates were the most predominant (5240/7659; 68.4%), including Klebsiella spp. (1766/5240; 33.7%), Acinetobacter baumannii (1613/5240; 30.8%), and Escherichia coli (582/5240; 11.1%). Gram-positive isolates (1728/7659; 22.6%) predominantly included Staphylococcus aureus (953/1728; 55.1%) and Enterococcus spp. (747/1728; 43.2%). Carbapenem resistance was common in Gram-negative infections, particularly in A. baumannii (1253/1554; 80.6%) and Klebsiella spp. (1209/1697; 71.2%). Among Gram-positive, S. aureus exhibited a high level of resistance to methicillin (529/748; 70.7%).

CONCLUSIONS

This surveillance study underscores the need to expand infection prevention and control strategies to include non-device-associated risk factors. This will lead to the formulation of comprehensive infection prevention and control programs, mitigating the burden and clinical outcomes of non-CLABSI.

Для цитирования: Srivastava Ashish Kumar, Thakur Arpan Kumar, Singh Kumari Vandana, Parveen Rasna, Puraswani Mamta, Singh Parul, Chakrabarti Arunaloke, Rodrigues Camilla, Ray Pallab, Biswal Manisha, Taneja Neelam, Rudramurthy Shivaprakash M, Angrup Archana, Sehgal Inderpaul, Agarwal Ritesh, Wattal Chand, Venkatesh Vimala, Sethuraman Nandini, Bhattacharya Sanjay, Nag Vijaya Lakshmi, Tak Vibhor, Behera Bijayini, Hallur Vinaykumar, Balaji Veeraragavan, Ray Raja, Singh Sanjeev K, Mukhopadhyay Chiranjay, Michael Joy Sarojini, Fomda Bashir Ahmad, Karuna Tadepalli, Deotale Vijayshri, Prasad Amber, Majumder Tapan, Gupta Puneet Kumar, Padmaja Kanne, Bajpai Vijeta, Iravane Jyoti, Nath Reema, Gur Renu, Lyngdoh Nari M, Lyngdoh Clarissa, Devi Sheela, Malhotra Shalini, Gaind Rajni, Khuraijam Ranjana Devi, Sharma Rajni, Mullan Summaiya, Prakash John Antony Jude, Basu Shaoli, Paul Hema, Rupali Priscilla, Verma Sheetal, Thirunarayan M A, Raj Hirak Jyoti, Saxena Rushika, Rajdev Sangita, Goel Neeraj, Mukherjee Sudipta, Ramanathan Yamunadevi V, Chelliah Juliah, Mukherjee Satyam, Sonowal Aparna, Gupta Sharmila Sen, Verma Prachi, Muralidharan Jayashree, Yaddanapudi Lakshmi Narayana, Duseja Ajay, Jain Kajal, Dutta Usha, Bhattacharyya Parthasarathi, Mahapatra Ashoka, Som Tapas Kumar, Das Rashmi Ranjan, Tripathy Swagata, Mishra Tushar, Dey Anupam, Ke Vandana, Varma Muralidhar, Omar Balram Ji, Aggarwal Ankit, Baqal Sherish, Singh Langpoklakpam Chaoba, Gupta Neeraj, Bhatia Pradeep Kumar, Singh Kuldeep, Khera Daisy, Himanshu D, Gupta Sarika, Arshad Zia, Bhabor Ullash, Sarode Rahul, Pradhan Satyajit, Krishnamoorthi Sivanantham, Duggal Shalini Dewan, Kumar Rajender, Kaushal G P, Dabas Vikas, Kumar Subodh, Soni Kapil Dev, Sagar Sushma, Aggarwal Richa, Singh Gyaninder Pal, Bindra Ashish, Farooque Kamran, Walia Kamini, Mathur Purva. Epidemiology of non-central line-associated primary bloodstream infections in a network of Indian hospitals: A prospective surveillance study over 7 years (2017-2024).. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2025. DOI: 10.1016/j.ijid.2025.108126.

Предметные рубрики MeSH

Humans India Prospective Studies Male Female Cross Infection Middle Aged Bacteremia Intensive Care Units Adult Tertiary Care Centers Anti-Bacterial Agents Aged Epidemiological Monitoring Young Adult Adolescent Catheter-Related Infections Child, Preschool Infant

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