[The pathogenesis, early diagnosis, and pharmacocorrection of fetal condition disturbances in high risk pregnancy].

A longitudinal retrospective study of 803 women and a prospective study of 739 women were carried out. A complex system of the examination of women with a high placental insufficiency risk, starting from the first trimester, was developed; the appropriateness of the application of new technologies of placental system and fetal examination were substantiated. The authors offer optimal regimens of pharmacocorrection of fetal condition disturbances and the activation of compensatory and adaptive reactions of the fetoplacental complex in placental insufficiency of various origins. The optimal obstetric tactics, the possibilities of therapy and pregnancy prolongation, and indications to operative delivery were defined on the basis of the features of placental dysfunction pathogenesis and a thorough analysis of the features of placental insufficiency in women with a high risk of perinatal complications.