Advances in m6A Modification in Pregnancy-Related Disorders and Female Reproductive Endocrine Diseases.

N6-methyladenosine (m6A) is the most abundant internal RNA modification and has emerged as an important regulator of reproductive biology. Dysregulation of m6A regulators has been implicated in pregnancy-related disorders, including recurrent implantation failure, miscarriage, preeclampsia, and gestational diabetes, as well as female reproductive endocrine diseases such as polycystic ovary syndrome, premature ovarian insufficiency, and endometriosis. In this review, we summarize current evidence on the roles of m6A writers, erasers, and readers in these disorders, with particular attention to tissue specificity, model systems, downstream targets. We further discuss major sources of inconsistency across studies, including differences in disease stage, cell type, assay platform, and confounding factors. By integrating mechanistic findings with current limitations in the field, this review provides an updated framework for understanding the biological significance of m6A in female reproductive health and disease.