Pediatric exercise science · 2026
Retrospective Study Exploring Changes in Respiratory Rate and Tidal Volume During Exercise Testing in Patients With Unexplained Exercise Intolerance.
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Durbin William, Foster Karla, Brown Elliot, Powell Adam W, Hardie William D
Аннотация
PURPOSE: Dysfunctional breathing contributes to exercise intolerance (EI) but is difficult to diagnose. We developed a novel approach to evaluate the ventilatory response during cardiopulmonary exercise tests (CPET), measuring the average change in respiratory rate (RR) relative to the change in tidal volume (Vt). We hypothesized that this RR:Vt slope ratio will uncover unique ventilatory responses among different groups of patients experiencing EI.
METHODS: An exploratory retrospective review was conducted on CPET for patients with EI from January 2017 to July 2024. Demographics, spirometry, CPET, and auscultatory findings of stridor during exercise were compared among patients with an elevated RR:Vt to patients with a lower RR:Vt ratio with and without stridor.
RESULTS: CPET from 65 patients, mean age 14.8 (9-20) years, were compared among those with an elevated RR:Vt ratio (21 patients, ratio 43.0) and patients with a lower RR:Vt ratio with stridor (19 patients, ratio 22.6) and without stridor (25 patients, ratio 22.1). Patients with an elevated RR:Vt were younger with reduced Vt and minute ventilation expansion at peak exercise with no differences in peak oxygen uptake.
CONCLUSION: Groups of patients with EI exhibit a higher RR:Vt ratio, reflecting an altered breathing pattern that may be consistent with dysfunctional breathing.
METHODS: An exploratory retrospective review was conducted on CPET for patients with EI from January 2017 to July 2024. Demographics, spirometry, CPET, and auscultatory findings of stridor during exercise were compared among patients with an elevated RR:Vt to patients with a lower RR:Vt ratio with and without stridor.
RESULTS: CPET from 65 patients, mean age 14.8 (9-20) years, were compared among those with an elevated RR:Vt ratio (21 patients, ratio 43.0) and patients with a lower RR:Vt ratio with stridor (19 patients, ratio 22.6) and without stridor (25 patients, ratio 22.1). Patients with an elevated RR:Vt were younger with reduced Vt and minute ventilation expansion at peak exercise with no differences in peak oxygen uptake.
CONCLUSION: Groups of patients with EI exhibit a higher RR:Vt ratio, reflecting an altered breathing pattern that may be consistent with dysfunctional breathing.