Copper-Catalyzed Domino Reaction of Isocyanides with Carboxylic Acids and PhSO2SeCH3 to Access Se-CH3 Selenocarbamates.

We described a new path for the preparation of Se-CH3 selenocarbamates from readily accessible carboxylic acids, isocyanides, and PhSO2SeCH3 with the formation of new C-Se and C-N bonds. This protocol is not only suitable for late-stage derivatization of carboxylic acid drugs but also permits double reactions of three-component reactions. Most importantly, compound 4t possesses potential antioxidant activity and may alleviate oxidative stress damage by regulating the Nrf2 signaling pathway.