Chemistry & biodiversity · 2026
Nudiloid Z, a New Labdane-Type Diterpenoid From Callicarpa nudiflora With Anti-Inflammatory Activity.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Qi, Li Bo, Tang Yan-Ling, Ji Xue-Ting, Zeb Muhammad Aurang, Ma Yan-Zi, Kong Yuan-Lin, Liang Zhong-Dan, Li Xiao-Li, Zhang Xing-Jie, Xiao Wei-Lie
Аннотация
A new labdane-type diterpenoid, Nudiloid Z (1), together with twelve known compounds (2-13), were isolated and purified from the stems and leaves of Callicarpa nudiflora. Compound 1 possesses a three-membered epoxide ring at C-12 and C-13. The planar structure and absolute configuration of 1 were elucidated by comprehensive spectroscopic analyses. The inhibitory effects of compounds 1-3 and 8 on lactate dehydrogenase (LDH) release in J774A.1 cell was evaluated. The results indicated that compound 1 exhibited significant anti-inflammatory activity, with an inhibitory concentration 50% (IC50) value of 3.30 ± 0.47 µM on LDH release and reduced the Interleukin 1β (IL-1β) levels in a dose-dependent manner.
Предметные рубрики MeSH
DiterpenesAnimalsCallicarpaMicePlant LeavesInterleukin-1betaCell LinePlant StemsL-Lactate DehydrogenaseAnti-Inflammatory AgentsMacrophagesMolecular ConformationMolecular StructureDose-Response Relationship, DrugStructure-Activity RelationshipAnti-Inflammatory Agents, Non-SteroidalLipopolysaccharides