Neurodevelopment of children exposed and unexposed to Zika virus in pregnancy: a cross-sectional analysis.

This article aims to assess the neurodevelopment of children with and without in utero Zika virus (ZIKV) exposure, in the absence of microcephaly at birth, and to explore social and biological factors associated with develop- mental outcomes. Cross-sectional analysis of 172 children (94 ZIKV-exposed, 78 unexposed), aged 11-39 months, were evaluated using the Bayley Scales of Infant and Toddler Development. . Outcomes were classified as delayed (<70) or at risk (70-84) across cognitive, language, and motor domains. Exposure was confirmed by maternal RT-P- CR or neonatal IgM. Overall, 30.8% of children presented with developmental delay or risk in at least one domain. The most affected domain was language (26.7%). There were no statistically significant differences in delay frequency cognitive and motor domains.