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Evaluation of Annona muricata for hepatoprotection, hematological assessment and inhibitor of TGFβR1 in liver diseases.
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Ololade Zacchaeus S, Anuoluwa Iyadunni A, Onifade Olayinka F, Adeagbo Adewumi I, Oyebanji Olawumi T, Asaju Ademola O, Eze John C
Аннотация
BACKGROUND: This study was conducted to assess the hepatoprotective potential of Annona muricata flower (AMF) using albino rats' model.
MATERIALS AND METHODS: Liver function assays such as alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBILI), antioxidants, haematology (HGB), histology, inhibition of transforming growth factor beta receptor I (TGFβR1) and antibacterial assays were investigated.
RESULTS AND DISCUSSION: Induction with acetaminophen gave rise to a significant increase (p < 0.05) in serum of liver enzymes of ALT, AST, ALP and TBILI in the acetaminophen (APAP) only group, which indicates hepatocellular injury, whereas AMF attenuated liver enzymes level. The histological assessment confirmed that AMF possesses blood-enhancing ability. AMF significantly showed inhibition of TGFβR1. AMF was active against all the tested bacteria with high zones of inhibition.
CONCLUSION: This study provides information on the uses of AMF as a natural product for hepatoprotection and other therapeutic purposes.
MATERIALS AND METHODS: Liver function assays such as alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBILI), antioxidants, haematology (HGB), histology, inhibition of transforming growth factor beta receptor I (TGFβR1) and antibacterial assays were investigated.
RESULTS AND DISCUSSION: Induction with acetaminophen gave rise to a significant increase (p < 0.05) in serum of liver enzymes of ALT, AST, ALP and TBILI in the acetaminophen (APAP) only group, which indicates hepatocellular injury, whereas AMF attenuated liver enzymes level. The histological assessment confirmed that AMF possesses blood-enhancing ability. AMF significantly showed inhibition of TGFβR1. AMF was active against all the tested bacteria with high zones of inhibition.
CONCLUSION: This study provides information on the uses of AMF as a natural product for hepatoprotection and other therapeutic purposes.